A systems approach reveals species differences in hepatic stress response capacity
G. Russomanno, R. Sison-Young, L. A. Livoti, H. Coghlan, R. E. Jenkins, S. J. Kunnen, C. P. Fisher, D. Reddyhoff, I. Gardner, A. H. Rehman, S. W. Fenwick, A. R. Jones, G. Vermeil De Conchard, G. Simonin, H. Bertheux, , I. M. Copple
The paper compares hepatic stress responses in mice and rats using pharmacokinetic modeling and omics data, finding greater liver injury in mice despite similar toxicant exposure.
bioRxiv · Apr 13, 2022Pharmacology & Toxicology