Novel Laser Capture Microdissection-Proteomic Analysis Identifies Spatially Distinct Extracellular Matrix Signatures in the Core and Infiltrating Edge of Human Glioblastoma.
R. Pedley, D. T. Prescott, E. Appleton, L. Dingle, J. Minshull, P. I. D'Urso, I. Djoukhadar, A. P. Gilmore, F. Roncaroli, J. Swift
This paper develops an LCM-proteomics protocol to analyze spatial ECM differences in human glioblastoma, identifying distinct matrisome components between tumor epicenter and brain/tumor interface.
bioRxiv · Sep 1, 2022 · PreprintCancer Biology