Histone Tail Electrostatics Modulate E2-E3 Enzyme Dynamics: A Gateway to Regulate Ubiquitination Machinery
D. T. S. Ranathunga, H. Torabifard
This study uses molecular dynamics simulations to reveal how histone tail electrostatics influence BRCA1/BARD1-UbcH5c dynamics and ubiquitination of the H2A C-tail, linking these processes to cancer susceptibility.
bioRxiv · Aug 27, 2022Biophysics