HNRNPC-mediated RNA processing promotes VHL-associated excessive vasculogenesis in von Hippel-Lindau syndrome revealed from patient-derived blood vessel models
Hidenori Ito, Iori Sato, Mami Matsuo-Takasaki, Tomoya Shimizu, Michiya Noguchi, Yukio Nakamura, Naoki Kubo, Daigo Takagi, Masaru Tamura, Megumu K Saito, Shunsaku Takayanagi, Nobuhito Saito, Eijiro Nakamura, Yohei Hayashi
This study uses patient-derived iPSCs to model VHLS-associated excessive vasculogenesis and identifies HNRNPC as a key factor in VHL-driven vascular lesions independent of HIF2A.
bioRxiv · Nov 2, 2026 · PreprintCell Biology