The circadian oscillator analysed at the single-transcript level
Nick E. Phillips, Alice Hugues, Jake Yeung, Eric Durandau, Damien Nicolas, Félix Naef
The paper measures single-cell mRNA dynamics of core-clock genes in mouse fibroblasts and develops a probabilistic model to decompose mRNA variability, showing circadian phase is encoded post-transcriptionally.
Molecular Systems Biology · Mar 1, 2021Peer-reviewedSystems Biology