Jake Yeung

Fishash assigns perturbations to cells in Perturb-seq data using Fisher's Exact Test, improving accuracy and speed over existing methods.

The paper identifies a female-selective corticosterone-mediated microglia-neuron interaction during ketamine anesthesia recovery that drives neuronal plasticity.

This paper improves Perturb-seq by analyzing guide multiplets, reducing costs and maintaining signal recovery.

The paper compares spinal cord cell types across vertebrates, finding conserved developmental programs and divergent adult compositions, with mammalian-specific neuropeptide expression in the dorsal spinal cord.

The paper introduces scChIX, a method to map multiple histone modifications in single cells by combining experimental and computational approaches, revealing chromatin state transitions in immune cells.

The paper develops sortChIC to map histone modifications in mouse hematopoietic cells, revealing hierarchical chromatin regulation during blood formation.

The paper measures single-cell mRNA dynamics of core-clock genes in mouse fibroblasts and develops a probabilistic model to decompose mRNA variability, showing circadian phase is encoded post-transcriptionally.

The paper investigates circadian rhythms in liver chromatin organization and transcription, finding both clock-controlled and clock-independent chromatin structures regulate physiological functions.

This study examines how sleep deprivation affects gene expression and chromatin accessibility in mice, revealing long-term genomic regulatory changes.

The paper investigates how circadian gene expression is regulated across tissues by analyzing transcription factor activity rhythms and chromatin interactions in mouse tissues.