A cingulate-hippocampal circuit mediates early depressive symptoms in Alzheimer's disease
Yanbing Chen, Huimin Peng, Kai Zhuang, Wenting Xie, Chenli Li, Jin Xue, Meiqin Chen, Xiaoting Huang, Tingting Zou, Ya Wang, Dan Can, Huifang Li, Ti‐Fei Yuan, Jie Zhang
This study identifies the ACC-vCA1 circuit as a neural substrate for depressive symptoms in Alzheimer's disease and shows that modulating this circuit can alleviate depressive-like behaviors and cognitive impairment.
bioRxiv · Feb 7, 2023 · PreprintNeuroscience