Deaminase-assisted single-molecule and single-cell chromatin fiber sequencing
Elliott G. Swanson, Yizi Mao, Benjamin J. Mallory, Mitchell Robert Vollger, Stephanie C. Bohaczuk, Christopher B. Oliveira, Daniel B. Lyon, Jane E. Ranchalis, Nancy L. Parmalee, Barak A. Cohen, James T. Bennett, Andrew B. Stergachis
This paper introduces DAF-seq, a method for single-molecule and single-cell chromatin fiber sequencing, enabling precise analysis of protein occupancy and chromatin accessibility.
Nature Biotechnology · Dec 3, 2025Peer-reviewedGenomics