Charged mutations in the FUS low-complexity domain modulate condensate ageing kinetics
Eduardo Pedraza, Daniel Hoyos, Alejadro Feito, Francisco Gámez, Ignacio Sanchez‐Burgos, Rosana Collepardo‐Guevara, Andrés R. Tejedor, Jorge R. Espinosa
This study uses simulations to show how charged mutations in FUS affect condensate ageing kinetics by altering β-sheet accumulation and aggregate formation.
bioRxiv · Mar 26, 2025 · PreprintBiophysics