Ignacio Sanchez‐Burgos

This study shows RNA synthesis and degradation dynamically regulate transcriptional condensates through non-equilibrium feedback, affecting their composition and stability.

This study shows that cross-β-sheet nucleation, linked to ageing, preferentially occurs at biomolecular condensate interfaces due to a general physical mechanism, not specific protein sequences.

This study uses all-atom simulations to analyze nucleotide-nucleotide and nucleotide-amino acid interactions, revealing key binding modes and their role in biomolecular condensate formation.

This study uses molecular dynamics simulations to reveal how misfolded α1-antitrypsin forms liquid-like droplets that harden into solid clusters, explaining the pathogenesis of α1-antitrypsin deficiency.

The paper designs a computational pipeline to identify small peptides that slow condensate ageing in TDP-43 and FUS by reducing condensate density through electrostatic interactions.

This study uses simulations to show how charged mutations in FUS affect condensate ageing kinetics by altering β-sheet accumulation and aggregate formation.

This study uses Molecular Dynamics simulations to show how different biomolecules affect the ageing kinetics of TDP-43 condensates, with arginine-rich peptides accelerating and poly-Uridine RNA slowing the formation of harmful cross-β-sheet structures.

This study benchmarks six residue-resolution coarse-grained models to evaluate their accuracy in simulating the phase behavior and material properties of hnRNPA1 LCD condensates.

This study evaluates five coarse-grained protein models for predicting phase diagrams of hnRNPA1 LCD mutants, finding that only three accurately reproduce experimental data, highlighting the need to balance single-molecule and collective properties.

This study investigates how the fusion of biomolecular condensates, influenced by ageing and mixing rates, leads to the formation of multiphase structures with distinct material properties.