Optimizing DNA origami assembly through selection of scaffold sequences that minimise off-target interactions
Ben Shirt‐Ediss, Emanuela Torelli, Silvia Adriana Navarro, Hadeel Khamis, Ariel Kaplan, William Trewby, Juan Elezgaray, Nima Moradzadeh, Michael W. Haydell, Daniel Keppner, Michael Famulok, Natalio Krasnogor
This paper develops a computational method to select DNA origami scaffold sequences that minimize off-target interactions, validated through AFM and optical tweezers experiments.
bioRxiv · Jan 29, 2025 · PreprintBioengineering