Interleukin-36 upregulates type-I interferon responses in systemic lupus erythematosus by promoting the accumulation of self-nucleic acids
Emma J. Welsh, Daniel McCluskey, Patrick Baum, Myles Lewis, Francesca Capon
This study shows IL-36 promotes monocyte apoptosis and downregulates nucleic acid clearance, leading to self-nucleic acid accumulation and enhanced type-I IFN responses in SLE.
Frontiers in Immunology · Jan 13, 2026Peer-reviewedImmunology