Francesca Capon

This study shows IL-36 promotes monocyte apoptosis and downregulates nucleic acid clearance, leading to self-nucleic acid accumulation and enhanced type-I IFN responses in SLE.

This study shows that IL-36γ signaling reduces the anti-inflammatory M2a macrophage state by decreasing CD163 and lipid uptake receptors, while increasing M1 markers and cytokines.

This study performs a GWAS meta-analysis of psoriasis, identifying 109 susceptibility loci, including 45 new ones, and highlights potential therapeutic targets and disease mechanisms.

This paper conducts a genome-wide meta-analysis of palmoplantar pustulosis, identifying genetic associations with Th2 responses and cigarette smoking.

The paper identifies MPO mutations as genetic determinants of pustular skin disease and increased neutrophil counts through exome sequencing and UK Biobank analysis.

The paper identifies an IL-36/TLR-9/Type-I IFN axis that drives systemic inflammation in psoriasis, offering a potential therapeutic target.