Structure of E3 ligase E6AP with a novel proteasome-binding site provided by substrate receptor hRpn10
Gwen R. Buel, Xiang Chen, Raj Chari, Maura J. O’Neill, Danielle L. Ebelle, Conor Jenkins, Vinidhra Sridharan, Sergey G. Tarasov, Nadya I. Tarasova, Þorkell Andrésson, Kylie J. Walters
The paper identifies a novel proteasome-binding site in E6AP mediated by hRpn10, showing E6AP's unique interaction with the proteasome for substrate ubiquitination.
Nature Communications · Mar 10, 2020Peer-reviewedMolecular Biology