Crystal structure and catalytic mechanism of PL35 family glycosaminoglycan lyases with an ultrabroad substrate spectrum
Lin Wei, Hai-Yan Cao, Ruyi Zou, Min Du, Qingdong Zhang, Danrong Lu, Xiangyu Xu, Yingying Xu, Wenshuang Wang, Xiu‐Lan Chen, Yu‐Zhong Zhang, Fuchuan Li
This study determines the crystal structures of two PL35 family GAG lyases and investigates their catalytic mechanism, revealing structural evidence for their divergent evolution from alginate lyases.
bioRxiv · Sep 4, 2024Biochemistry