Pulmonary maternal immune activation does not extend through the placenta but leads to fetal metabolic adaptation
Signe Schmidt Kjølner Hansen, Robert Krautz, Daria Rago, Jesper Foged Havelund, Nils Joakim Færgeman, Audrey Prézelin, Julie Rivière, Anne Couturier‐Tarrade, Vyacheslav Akimov, Blagoy Blagoev, Betina Elfving, Arnaud Stigliani, Ulla Birgitte Vogel, Konstantin V. Khodosevich, Karin Sørig Hougaard, Albin Sandelin
The paper examines the temporal response to maternal pulmonary immune activation across maternal and fetal organs using multi-omics, finding that the placenta protects the fetus through metabolic adaptations rather than immune responses.
bioRxiv · Mar 17, 2023 · PreprintGenomics