Konstantin V. Khodosevich

Spatial navigation through evolution: a single-cell atlas of the mammalian entorhinal cortex

The paper presents a cross-species single-cell atlas of the entorhinal cortex across mammals, identifying conserved and species-specific cellular innovations related to spatial navigation.

Defining the Vascular Niche of Human Adipose Tissue Across Metabolic States

The paper creates a single-cell transcriptome atlas of human subcutaneous adipose tissue vascular cells, identifies sub-AdECs, and links their properties to metabolic disease.

Male obesity causes adipose mitochondrial dysfunction in F1 progeny via a let-7-DICER axis.

This study shows that male obesity affects adipose mitochondrial function in offspring via the let-7-DICER axis, with reversible effects observed in both mice and human semen.

Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit

The paper identifies spatially distinct fibroblast and myonuclei subtypes in human muscle-tendon units that respond to mechanical loading by remodeling the extracellular matrix.

Circuits activated by psychiatric-associated behavior: from brain-wide labeling to regional assessment using Psych-TRAP.

The paper introduces Psych-TRAP, a method to label brain circuits activated during psychiatric-relevant behavior, and shows its application in a 15q13.3 microdeletion mouse model, revealing circuit-specific GABAergic alterations.

A postnatal molecular switch drives the activity-dependent maturation of parvalbumin interneurons

This study identifies a molecular switch driven by neuronal activity and PGC-1 that promotes the maturation of parvalbumin interneurons during postnatal development.

Early postnatal CA3 hyperexcitability drives hippocampal development and epileptogenesis in SCN2A developmental and epileptic encephalopathy

This study shows that early postnatal CA3 hyperexcitability drives hippocampal development and epileptogenesis in SCN2A-DEE, suggesting it as a therapeutic target.

Single-cell profiling of cortical tubers in tuberous sclerosis complex shows molecular structure preservation and massive reorganization of metabolism

The paper uses single-nucleus RNA sequencing to analyze cortical tubers in TSC, finding preserved neuronal subtypes and metabolic reorganization in neurons.

A single dose of cocaine rewires the 3D genome structure of midbrain dopamine neurons

This study shows that a single cocaine exposure causes long-lasting 3D genome structure changes in midbrain dopamine neurons, affecting gene regulation and synaptic plasticity.

Single-Cell Atlas Uncovers Layer 4 Heterogeneity and Functional Gradients in Rhesus Macaque Visual Cortex

The paper uses snRNA-seq to analyze layer 4 heterogeneity in rhesus macaque visual cortex, identifying distinct subtypes and linking them to neurodevelopmental disorders.

Pulmonary maternal immune activation does not extend through the placenta but leads to fetal metabolic adaptation

The paper examines the temporal response to maternal pulmonary immune activation across maternal and fetal organs using multi-omics, finding that the placenta protects the fetus through metabolic adaptations rather than immune responses.

Selective vulnerability of supragranular layer neurons in schizophrenia

The paper identifies selective vulnerability of supragranular layer neurons in schizophrenia through single nucleus RNA sequencing and histological analysis.

Case-control analysis of single-cell RNA-seq studies

Cacoa packages statistical tests, exploration and plots for comparing groups of scRNA-seq samples, aimed at inter-individual variability, small cohorts and high-dimensional data.

Development of the entorhinal cortex occurs via parallel lamination during neurogenesis.

This study characterizes the development of the entorhinal cortex in pigs and mice, revealing a parallel lamination pattern during neurogenesis that differs from neocortical lamination.

Decoding the porcine developing spatial processing system and production of human entorhinal stellate cell-like cells by a direct programming approach.

The paper uses single-cell RNA sequencing to study porcine medial entorhinal cortex development and demonstrates the production of human entorhinal stellate cell-like cells from pluripotent stem cells.

Bayesian segmentation of spatially resolved transcriptomics data

This paper introduces Baysor, a Bayesian segmentation tool for spatial transcriptomics data that improves cell identification and reduces contamination across multiple protocols.

Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner

This study shows maternal inflammation impairs specific stages and subtypes of cortical GABAergic interneuron development, leading to structural and functional changes in the offspring's brain.

Wiring together large single-cell RNA-seq sample collections

The paper introduces Conos, a method for joint clustering of large single-cell RNA-seq datasets to identify recurrent cell subpopulations across multiple samples.

Genomic normalization for sequencing libraries enrichment for rare somatic retroelement insertions

This study develops a normalization procedure to enhance detection of rare somatic retroelement insertions in sequencing libraries, increasing identified insertions by 7.9-fold.