TDP-43 pathology induces CD8+ T cell activation through cryptic epitope recognition
Shahab Chizari, Matteo Zanovello, Steven Lingyang Kong, Vidur J. Saigal, Anna‐Leigh Brown, Valentina Turchetti, Bingxian Chen, Connor C. Devine, Luca Zampedri, Iwona Skorupinska, Giacomo Maria Minicuci, Francesca Paron, Paola Tonin, Giulia Marchetto, Ziyi Li, , Ning Jenny Jiang
This study identifies cryptic epitopes from de novo proteins caused by TDP-43 pathology as targets of CD8+ T cell activation in ALS and IBM.
bioRxiv · Jun 22, 2025 · PreprintImmunology