Author

Dario Wirtz

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:sequence-to-function modeling· 1 Approach:statistical model· 1

Frequent Co-Authors

Claus HorniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

1 paper

Recent·Most cited

Geometric Protein Optimization

Dario Wirtz, Claus Horn

This paper introduces Geometric Protein Optimization (GPO), an AI framework that improves protein-ligand binding affinity by optimizing global geometry through diverse substitutions, achieving significant in silico improvements.

bioRxiv · Feb 10, 2025 · PreprintBiochemistry