Deep Brain Stimulation Microelectrodes as a Source of Human Subcortical RNA: Validation of a Low-Input Transcriptomic Protocol
Sandeep Sandeep, Arti Saini, Vivek Chouhan, Sanskriti Rai, Divya Madathiparambil Radhakrishnan, Ümran Yaman, Arunmozhimaran Elavarasi, Divyani Garg, Animesh Das, Thyagarajan Radhakrishnan, Anu Gupta, Mamta Bhushan Singh, Venugopalan Y. Vishnu, Saroj Kumar, Abhishek Yadav, , Roopa Rajan
This paper validates a low-input RNA extraction protocol using DBS microelectrodes to obtain subcortical RNA from post-mortem brains, confirming brain origin and sub-regional cellular identity.
bioRxiv · Jul 30, 2026 · PreprintGenetics