This study evaluates LAM detection in CSF and urine and host inflammatory biomarkers for diagnosing and prognosticating tuberculous meningitis, finding high specificity for LAM and strong diagnostic performance for IL-1β.

Infection · Oct 8, 2026Peer-reviewedMicrobiology

Deep Brain Stimulation Microelectrodes as a Source of Human Subcortical RNA: Validation of a Low-Input Transcriptomic Protocol

Sandeep Sandeep, Arti Saini, Vivek Chouhan, Sanskriti Rai, Divya Madathiparambil Radhakrishnan, Ümran Yaman, Arunmozhimaran Elavarasi, Divyani Garg, Animesh Das, Thyagarajan Radhakrishnan, Anu Gupta, Mamta Bhushan Singh, Venugopalan Y. Vishnu, Saroj Kumar, Abhishek Yadav, , Roopa Rajan

This paper validates a low-input RNA extraction protocol using DBS microelectrodes to obtain subcortical RNA from post-mortem brains, confirming brain origin and sub-regional cellular identity.

bioRxiv · Jul 30, 2026 · PreprintGenetics

Length-dependent RNA foci formation and RAN translation are associated with SCA12 disorder

Manish Kumar, Shweta Sahni, Vivek Anand, Deepak Kumar, Neetu Singh Kushwah, Divya Goel, Himanshi Kapoor, Achal Kumar Srivastava, Mohammed Faruq

This study identifies molecular signatures of SCA12 by analyzing patient-derived neuronal cell lines and shows CAG repeat expansion leads to RNA foci and RAN translation.

bioRxiv · Jul 21, 2023 · PreprintNeuroscience

Investigation of RFC1 tandem nucleotide repeat locus in diverse neurodegenerative outcomes in an Indian cohort

Nishu Tyagi, Bharathram Uppili, Pooja Sharma, Shaista Parveen, Sheeba Saifi, Abhinav K. Jain, Akhilesh Kumar Sonakar, Istaq Ahmed, Shweta Sahni, Uzma Shamim, Avni Anand, Varun Suroliya, Asokachandran Vivekanand, Achal Kumar Srivastava, Sridhar Sivasubbu, , Mohammed Faruq

The paper investigates the prevalence and association of RFC1 tandem nucleotide repeat expansions with neurodegenerative diseases in an Indian cohort.

medRxiv · Jun 5, 2023 · PreprintGenetic & Genomic Medicine

Computational and experimental hunt for expansion prone tandem CNG repeats in human genomes

Varun Suroliya, Bharathram Uppili, Manish Kumar, Vineet Jha, Achal Kumar Srivastava, Mohammed Faruq

The paper combines computational and experimental methods to identify CNG repeat loci potentially linked to spinocerebellar ataxias, finding polymorphic patterns and expression in brain-related genes.

bioRxiv · May 3, 2023 · PreprintGenetics

Transcriptomic Dynamics of a non-coding trinucleotide repeat expansion disorder SCA12 in iPSC derived neuronal cells: signatures of interferon induced response

Deepak Kumar, Parashar Dhapola, Ashaq Hussain, Rintu Kutum, Achal Kumar Srivastava, Mitali Mukerji, Odity Mukherjee, Mohammed Faruq

This study establishes iPSC-derived neuronal cell lines for SCA12, identifies interferon signaling and inflammatory signatures as key transcriptomic features.

bioRxiv · Aug 21, 2018 · PreprintMolecular Biology