A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture
Henriette O'Geen, Isabelle M. Henry, Mital S. Bhakta, Joshua F. Meckler, David J. Segal
The paper analyzes Cas9 binding specificity using ChIP-seq and targeted sequence capture, finding high specificity at target sites and gRNA-independent off-target binding enriched in PAM sites.
Nucleic Acids Research · Feb 20, 2015Peer-reviewedMolecular Biology