Global Analysis of Human mRNA Folding Disruptions in Synonymous Variants Demonstrates Significant Population Constraint
Jeff Gaither, Grant Lammi, James Li, David M Gordon, Harkness C. Kuck, Benjamin Kelly, James Fitch, Peter White
The paper analyzes mRNA folding disruptions caused by synonymous variants and finds population-level constraints, introducing a Structural Predictivity Index to assess pathogenic potential.
GigaScience · Apr 1, 2021Peer-reviewedGenomics