Aurodox, a polyketide from Streptomyces goldiniensis, inhibits transcription of the type III secretion system of multiple Gram-negative pathogens
David Mark, Nicky O’Boyle, Kabo R Wale, Samantha K Tucker, Rebecca E McHugh, Andrew J Roe
This study investigates aurodox's effect on T3SS in multiple Gram-negative pathogens, showing it inhibits some but not all T3SS systems, with selectivity observed across different strains.
bioRxiv · Apr 19, 2024 · PreprintMicrobiology