Rebecca E. McHugh

This study analyzes genomic changes in Streptomyces clavuligerus strains during domestication, showing how mutations and rearrangements enhance antibiotic production while reducing metabolic flexibility.

The paper identifies the myelinic channel system as a pathway for microtubule-dependent organelle transport in oligodendrocytes, showing its role in maintaining axonal integrity through neuronal activity and motor proteins.

Antibiotic treatment of meningococcal and other sepsis causative bacteria triggers the release of histone-like proteins (HLPs) that damage the endothelium and drive coagulopathy, but these effects can be neutralized by non-anticoagulant heparins or anti-HLP antibodies.

The paper describes a low-cost 3D-printed optical microscope capable of sub-cellular resolution for histological imaging, using affordable components and open design for replication.

This study investigates aurodox's effect on T3SS in multiple Gram-negative pathogens, showing it inhibits some but not all T3SS systems, with selectivity observed across different strains.

The paper isolates and characterizes an E. coli O157:H7 strain from commercial specific-pathogen-free mice, revealing limitations in current screening systems.

The paper reports the genome sequence of Streptomyces goldiniensis ATCC 21386, which produces the polyketide aurodox, and identifies biosynthetic gene clusters.