Use of polygenic risk scores and other molecular markers to enhance cardiovascular risk prediction: Prospective cohort study and modelling analysis
Luanluan Sun, Lisa A M Pennells, Stephen K. Kaptoge, Christopher P. Nelson, Gad Abraham, Matthew Arnold, Steven Bell, Thomas R Bolton, Stephen Burgess, Frank Dudbridge, Qi Guo, Scott C. Ritchie, Eleni Sofianopoulou, David Stevens, John Russell Thompson, , Emanuele Di Angelantonio
This study evaluates how adding polygenic risk scores and clinical biochemistry markers to conventional CVD risk models improves prediction accuracy and informs statin therapy decisions in a UK primary care setting.
bioRxiv · Aug 22, 2019 · PreprintGenomics