Christopher P. Nelson

This study identifies distinct gene expression changes in human coronary artery endothelial cells under elevated flow compared to oscillatory and normal flow, highlighting unique regulatory effects on CAD-related pathways and alternative splicing.

This study examines associations between leukocyte telomere length and genomic, phenomic, and geographic factors in diverse U.S. populations, identifying novel loci and genes.

This study uses Mendelian randomisation to investigate a causal link between Metformin use and reduced abdominal aortic aneurysm risk, finding a statistically significant association.

The paper identifies 53 rare variants and 22 genes associated with telomere length using UK Biobank whole-genome sequences, highlighting their role in clonal haematopoiesis and disease.

This study investigates the relationship between genetically predicted leukocyte telomere length and lung cancer risk, finding a causal association and novel susceptibility loci.

This study identifies 17 genetic risk loci for spontaneous coronary artery dissection (SCAD), including 12 new ones, and highlights genes related to artery integrity and coagulation.

This study identifies 144 genetic loci associated with abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target through Mendelian Randomization and pre-clinical validation.

The paper uses bidirectional Mendelian randomization to show LTL lengthening increases CHIP risk, while CHIP accelerates LTL shortening, with modest mediation between CHIP and CAD via LTL.

The paper reports LTL measurements in 474,074 UK Biobank participants, identifying factors like age, sex, ethnicity, and white cell count associated with LTL variation.

A coronary artery disease GWAS of 181,522 cases among 1,165,690 participants yields 241 associations (54 new); an eight-predictor consensus nominates 185 candidate causal genes, 94 with ≥3 predictors.

This study identifies 14 genome-wide significant loci and a polygenic signature for myeloproliferative neoplasms, implicating hematopoietic stem cell function and self-renewal in disease risk.

This study evaluates how adding polygenic risk scores and clinical biochemistry markers to conventional CVD risk models improves prediction accuracy and informs statin therapy decisions in a UK primary care setting.

This study identifies 210 genetic loci associated with the PR interval through multi-ancestry GWAS, highlighting their role in cardiac conduction and cardiovascular disease.

This study conducts a large GWAS on heart failure, identifying 12 genetic loci with associations to CAD, atrial fibrillation, and reduced left ventricular function, and provides causal evidence for several risk factors.

This study identifies a genome-wide significant association between a variant in the KCND3 gene and early repolarization pattern on ECG, suggesting a genetic basis for this trait.

The paper identifies cis-epistasis at the LPA locus involving two SNPs that interact to modulate coronary artery disease risk and related traits.

This study identifies 46 novel genetic loci associated with alcohol consumption and suggests shared genetic mechanisms with neuropsychiatric disorders using GWAS and functional analyses.

This paper develops a genomic risk score for coronary artery disease using 1.7 million variants and tests it in UK Biobank, showing it outperforms conventional risk factors in predicting CAD risk.

This study identifies 6 new blood pressure loci and 48 genes involved in BP regulation using GWAS and gene expression data from blood and kidney tissues.