Grand paternal inheritance of an acquired metabolic trait induced by ancestral obesity is associated with sperm RNA
Jennifer E Cropley, Sally A Eaton, Alastair Aiken, Paul E Young, Eleni Giannoulatou, Joshua WK Ho, Michael E Buckland, Simon P Keam, Gyorgy Hutvagner, David T Humphreys, Katherine G Langley, Darren Henstridge, David Martin, Mark A Febbraio, Catherine M Suter
The paper shows that paternal obesity induces a metabolic phenotype in offspring that persists through multiple generations via sperm RNA changes.
bioRxiv · Mar 10, 2016 · PreprintGenetics