Plasma Contains Ultra-short Single-stranded DNA in Addition to Nucleosomal cfDNA
Jordan C. Cheng, Marco Morselli, Wei-Lun Huang, You Jeong Heo, Thalyta Pinheiro-Ferreira, Feng Li, Wei Fang, David Chia, Hua Jun, Kenneth D. Cole, Wu‐Chou Su, Matteo A. Pellegrini, David T. Wong
The paper introduces uscfDNA-seq, a method to sequence single-stranded cell-free DNA in plasma, revealing a novel population of ultrashort cfDNA with a modal size of 50nt.
bioRxiv · Aug 22, 2021 · PreprintGenomics