High-resolution QTL mapping with Diversity Outbred mice identifies genetic variants that impact gut microbiome composition
Florencia Schlamp, David Y Zhang, Juan Felipe Beltrán, Elissa J. Cosgrove, Petr Šimeček, Matthew M. Edwards, Julia K. Goodrich, Ruth E. Ley, Allan I Pack, Gary A. Churchill, Andrew G. Clark
This study uses 16S rRNA gene sequencing in Diversity Outbred mice to identify genetic variants affecting gut microbiome composition, finding significant heritability and novel QTLs related to immune and metabolic pathways.
bioRxiv · Jan 5, 2021 · PreprintGenetics