Matthew M. Edwards

The paper examines DNA replication timing in iPSCs, finding that some exhibit delayed replication at heterochromatic regions, which persists through differentiation and may affect their quality.

The paper identifies how SETX mutations cause genome instability in AOA2 by increasing transcription stress and impairing repair mechanisms.

The paper profiles DNA replication timing in haploid and diploid human ESCs, identifying delayed replication in autosomal regions and linking it to X chromosome dosage and polyploid cell underreplication.

This study identifies genetic regulators of DNA replication timing in human pluripotent stem cells, revealing a histone code and combinatorial regulatory mechanisms.

The paper curates and classifies genetic evidence for dilated cardiomyopathy (DCM), identifying 19 genes with strong or moderate evidence and highlighting gaps in understanding.

This study uses 16S rRNA gene sequencing in Diversity Outbred mice to identify genetic variants affecting gut microbiome composition, finding significant heritability and novel QTLs related to immune and metabolic pathways.