Genomics of primary chemoresistance and remission induction failure in pediatric and adult acute myeloid leukemia
Fiona C Brown, Paolo Cifani, Esther Drill, Jie He, Eric Still, Shan Zhong, Sohail Balasubramanian, Dean Pavlick, Bahar Yilmazel, Kristina M Knapp, Todd A Alonzo, Soheil Meshinchi, Richard M Stone, Steven M Kornblau, Guido Marcucci, , Alex Kentsis
The paper investigates genetic factors contributing to primary chemoresistance in AML using targeted sequencing of 670 genes in 107 AML cases, identifying mutations and overexpressed genes but finding they only partially explain resistance.
bioRxiv · Apr 30, 2016Cancer Biology