Multiple lesion inductions intensify central sensitization driven by neuroinflammation in a mouse model of endometriosis.
Madeleine E. Harvey, Mingxin Shi, Yeong Seok Oh, Debra A. Mitchell, Ov Daniel Slayden, James A. MacLean, Kanako Hayashi
This study shows that repeated endometriosis lesion inductions in mice increase neuroinflammation and central sensitization, leading to chronic pelvic pain.
bioRxiv · Jan 23, 2025 · PreprintMolecular Biology