Real-space heterogeneous reconstruction, refinement, and disentanglement of CryoEM conformational states with HetSIREN
David Herreros, Carlos P. Mata, Chari M. Noddings, Deli Irene, James Krieger, David A. Agard, Ming‐Daw Tsai, Carlos Óscar S. Sorzano, J.M. Carazo
HetSIREN is a deep learning method for CryoEM conformational state reconstruction and refinement, improving structural accuracy by decoupling pose and CTF information from conformational landscapes.
Nature Communications · Apr 22, 2025Peer-reviewedBioinformatics