Carlos P. Mata

This paper investigates the role of the N-terminal domain of the capsid protein in calicivirus assembly and stability, showing its interaction with the viral genome and its impact on capsid structure and mechanical properties.

The paper introduces FlexConsensus, an algorithm that merges conformational landscapes from different CryoEM heterogeneity methods into a shared consensus space to improve reliability and reproducibility.

This study identifies structural constraints in rotavirus spike protein loops that regulate proteolytic activation necessary for infectivity.

HetSIREN is a deep learning method for CryoEM conformational state reconstruction and refinement, improving structural accuracy by decoupling pose and CTF information from conformational landscapes.

The paper investigates the structural and functional impact of the S:A222V mutation in SARS-CoV-2, showing increased RBD opening and ACE2 binding without reducing neutralization capacity.

The paper identifies a novel endogenous retrovirus in hookworms with an envelope protein structurally similar to phlebovirus glycoproteins and functional fusogenic activity.

The paper uses X-ray footprinting to determine the secondary structures of bacteriophage MS2 RNA in different states, revealing packaging signals and the impact of the Maturation Protein on RNA conformation and capsid structure.