Cell-type specific transcriptional modulation by psilocybin induces sustained plasticity in mouse medial prefrontal cortex
Heike Schuler, Delong Zhou, Chloé Savignac, Vedrana Cvetkovska, Yiu-Chung Tse, Juliet Meccia, Joëlle Lopez, Ashot S. Harutyunyan, Jiannis Ragoussis, Danilo Bzdok, Rosemary C. Bagot
This study shows psilocybin induces cell-type specific transcriptional changes in mouse medial prefrontal cortex, with sustained neuroplastic effects mediated by 5-HT2C signaling in L5/6 NP neurons.
bioRxiv · Jan 8, 2025 · PreprintNeuroscience