Chloé Savignac

Mapping Alzheimer's neuropathology signatures to the whole brain transcriptome using machine learning data fusion

Cell type-specific logistic regression estimators trained on 427 ROSMAP prefrontal donors project Braak- and β-amyloid-like transcriptomic signatures onto the 108-region Siletti atlas, flagging brainstem, hypothalamic and rostral hippocampal regions.

Cell type transcriptomics reveal shared genetic mechanisms in Alzheimer's and Parkinson's disease

The paper identifies shared molecular mechanisms between Alzheimer's and Parkinson's disease by analyzing gene co-expression at sub-cell-type resolution using single-nucleus datasets.

Cell-type specific transcriptional modulation by psilocybin induces sustained plasticity in mouse medial prefrontal cortex

This study shows psilocybin induces cell-type specific transcriptional changes in mouse medial prefrontal cortex, with sustained neuroplastic effects mediated by 5-HT2C signaling in L5/6 NP neurons.

APOE ϵ2 vs APOE ϵ4 dosage shows sex-specific links to hippocampus-default network subregion co-variation

The paper examines how APOE ε2 and ε4 variants affect hippocampus-default network subregion co-variation, revealing sex-specific associations with lifestyle and health traits.