Author

Dennis Coombe

Computer Modelling Group (Canada)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Approach:statistical model· 1

Frequent Co-Authors

Jack A. TuszyńskiiD· 1 shared Mafiz UddiniD· 1 shared Vahid RezaniaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 1 mutual co-author link

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1 shared paperPhysiology

Jack A. TuszyńskiORCID

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2 papers

Recent·Most cited

A multiscale analysis of liver lobule fibrosis and its impact on drug propagation and metabolism - a DLA approach

Vahid Rezania, Dennis Coombe, Jack A. Tuszyński

This paper uses DLA methods to analyze collagen fiber self-assembly in liver lobules and its impact on drug transport and metabolism across multiple scales.

bioRxiv · Sep 3, 2026 · PreprintPhysiology

Drug Delivery Process Simulation - Quantifying the Conformation Dynamics of Paclitaxel and Cremophor EL

Mafiz Uddin, Dennis Coombe

This study uses molecular simulations to analyze the conformation dynamics of paclitaxel and cremophor EL in a drug delivery system, identifying energy states and structural behaviors.

PLoS ONE · May 12, 2025Peer-reviewedBiochemistry