Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescue
Deirdre D. Scripture-Adams, Kevin N. Chesmore, Florian Barthélémy, Richard T. Wang, Shirley Nieves‐Rodriguez, Derek W. Wang, Ekaterina I. Mokhonova, Emilie D. Douine, Jijun Wan, Isaiah Little, Laura Rabichow, Stanley F. Nelson, M. Carrie Miceli
The paper develops a method to isolate nuclei from frozen muscle samples and uses single nuclei transcriptomics to study dystrophin loss and rescue in human DMD and mdx mouse muscle.
Communications Biology · Sep 19, 2022Peer-reviewedGenetics