Cooperativity and Communication between the Active Sites of the Dimeric SARS-CoV-2 Main Protease
Sarah N. Zvornicanin, Ala M. Shaqra, Julia M. Flynn, Lauren E. Intravaia, Heidi Carias, Weiping Jia, Devendra Kumar Gupta, Stephanie A. Moquin, Dustin Dovala, Daniel N. A. Bolon, Brian A. Kelch, Celia A. Schiffer, Neşe Kurt Yılmaz
This study investigates how the two active sites of SARS-CoV-2 Mpro communicate and cooperate in catalysis using enzymatic assays, crystal structures, and engineered mutations.
Science Advances · Jan 16, 2026Peer-reviewedBiochemistry