Different alleles of the same gene vary in pleiotropy, often mediated through currency metabolite production
Deya Alzoubi, Abdelmoneim Amer Desouki, Martin J. Lercher
The paper shows that alleles with reduced enzyme function in metabolic genes cause increasing pleiotropy, often through effects on currency metabolites like ATP and NADPH.
Scientific Reports · Nov 16, 2018Peer-reviewedSystems Biology