DePARylation prevents DNA replication-driven PARP1 condensation
Petar-Bogomil Kanev, Vanya Milanova, Preslava Berkova, Dimitar Kutrovski, Kalina L. Tosheva, Radoslav Aleksandrov
This study shows that PARG inhibition leads to PARP1 condensation during DNA replication, highlighting Okazaki fragment maturation as a target for enhancing PARGi cytotoxicity.
bioRxiv · Aug 25, 2026 · PreprintMolecular Biology