Dual checkpoint blockade of glioblastoma with Anti-PD-1 and Anti-LAG-3 promotes expansion of tumor-reactive T cell clones along a unique pathway of differentiation
Mingshuang Wang, Yuntian Fu, Sadhana Bom, Yi Ning, Divij Matthews, Ming Zhang, Calixto‐Hope G. Lucas, John Hyunkuk Choi, Zhen Zeng, Tianbei Zhang, Hongkai Ji, Vasan Yegnasubramanian, JON D. WEINGART, Chetan Bettegowda, Kellie Nicole Smith, , Christina Jackson
This study examines how dual checkpoint blockade with Anti-PD-1 and Anti-LAG-3 affects T cell clones in glioblastoma, showing increased clonal expansion and differentiation into effector T cells.
bioRxiv · Sep 6, 2025 · PreprintImmunology