Chetan Bettegowda

This paper presents a functional atlas of the human central nervous system using high-resolution surface electrophysiology from 70 patients, revealing conserved electrophysiological patterns and enabling neuroprosthetic applications.

The paper designs an AND-gated CAR T cell receptor called MANTIS that uses extracellular size differences to spatially regulate signaling for precise antigen recognition.

This paper develops a mouse model of classical trigeminal neuralgia by intradural nerve root compression, showing neuropathic pain behaviors and pharmacological responsiveness.

This paper engineers effector cells resistant to bacterial toxins to deliver immunotoxins specifically to cancer cells and introduces a platform for therapeutic cell type development.

This study develops anti-9G4 CAR-T and TCR-T cells to selectively target autoreactive B cells in SLE, reducing immunosuppression and cytokine toxicity.

This study examines how dual checkpoint blockade with Anti-PD-1 and Anti-LAG-3 affects T cell clones in glioblastoma, showing increased clonal expansion and differentiation into effector T cells.

The paper identifies NXPE1 as a gene responsible for sialic acid O-acetylation in the human colon, linking it to mPAS staining differences through genetic and functional analyses.

This study uses machine learning to enhance focused ultrasound for BBB opening, improving nanoparticle delivery and tumor DNA detection in brain tumors.

A SMG1 inhibitor disrupts nonsense-mediated decay, increasing expression of neoantigens from truncating mutations and enhancing immune targetable peptides on cancer cells.