PRECISION EVOLUTIONARY MEDICINE: A COMPUTATIONAL GRAPH-THEORETICAL FRAMEWORK FOR PATHOGEN-SPECIFIC ANTIBIOTIC CYCLING IN MULTI-DRUG-RESISTANT GRAM-NEGATIVE INFECTIONS
Ibrahim Shuaibu, Mahrukh Khan, Diyaa Alkhamis, Anas Alkhamis, Mustapha Isa Ahmad
This paper develops a computational graph-theoretical framework to identify pathogen-specific antibiotic cycling protocols that suppress resistance by exploiting collateral sensitivity.
bioRxiv · Jan 18, 2026 · PreprintMicrobiology