Biophysical determinants of mutational robustness in a viral molecular fitness landscape
Manasi A. Pethe, Aliza B. Rubenstein, Dmitri Zorine, Sagar D. Khare
The paper maps the sequence-energetics-function relationship of the HCV NS3/4A protease, revealing mutational robustness and clustering of cleavable/uncleavable motifs.
bioRxiv · Aug 3, 2017 · PreprintBiophysics