Accelerating gene discovery by phenotyping whole-genome sequenced multi- mutation strains and using the sequence kernel association test (SKAT)
Tiffany A Timbers, Stephanie J Garland, Swetha Mohan, Stephane Flibotte, Mark Edgley, Quintin Muncaster, Vinci Au, Erica Li-Leger, Federico Rosell, Jerry Cai, Suzanne Rademakers, Gert Jansen, Donald G Moerman, Michel R Leroux
The paper uses a whole-genome sequenced multi-mutation C. elegans library with SKAT to identify genes associated with ciliated sensory neuron defects, uncovering novel genes like BGNT-1.1 linked to human ciliopathies.
PLOS Genetics · Aug 10, 2016Peer-reviewedGenomics