Identification of candidate master transcription factors within enhancer-centric transcriptional regulatory networks
Alexander Joel Federation, Donald R. Polaski, Christopher J. Ott, Angela H. S. Fan, Charles Y. Lin, James E. Bradner
The paper constructs transcriptional regulatory networks to identify master transcription factors in cell types and applies the method to chronic lymphocytic leukemia, showing efficacy of targeting these factors.
bioRxiv · Jun 12, 2018 · PreprintSystems Biology