Charles Y. Lin

Cellular Maturation of Oligodendrocytes is Governed by Transient Gene Melting

This study identifies a transcriptional mechanism that controls oligodendrocyte maturation through SOX6-mediated gene melting, showing that suppressing SOX6 accelerates maturation and that an immature SOX6 signature is enriched in multiple sclerosis patient brains.

Transcriptional plasticity drives leukemia immune escape

The paper identifies transcription factors regulating MHC-II expression in AML and shows their role in immune evasion and relapse.

A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia

The paper identifies a modular core regulatory circuitry in AML that enforces oncogene expression in KMT2A-rearranged leukemias.

Dynamic chromatin targeting of BRD4 stimulates cardiac fibroblast activation

This study shows BRD4 promotes cardiac fibrosis by dynamically targeting chromatin and activating gene expression in fibroblasts, revealing a signaling pathway involved in heart failure.

Identification of candidate master transcription factors within enhancer-centric transcriptional regulatory networks

The paper constructs transcriptional regulatory networks to identify master transcription factors in cell types and applies the method to chronic lymphocytic leukemia, showing efficacy of targeting these factors.