Modulation of lysosomal Cl- mediates migration and apoptosis through the TRPML1 as a lysosomal Cl- sensor
Dongun Lee, Dong Min Shin, Jeong Hee Hong
This study shows that reduced chloride levels trigger lysosomal calcium release via TRPML1, affecting migration and apoptosis, and identifies chloride-sensing motifs in TRPML1.
Cells · Jul 12, 2023Peer-reviewedMolecular Biology